Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer. Issue 1 (1st February 2015)

• Record Type: Journal Article
• Authors: Hao, Chuncheng; Wang, Li; Peng, Shaohua; Cao, Mengru; Li, Hongyu; Hu, Jing; Huang, Xiao; Liu, Wei; Zhang, Hui; Wu, Shuhong; Pataer, Apar; Heymach, John V.; Eterovic, Agda Karina; Zhang, Qingxiu; Shaw, Kenna R.; Chen, Ken; Futreal, Andrew; Wang, Michael; Hofstetter, Wayne; Mehran, Reza; Rice, David; Roth, Jack A.; Sepesi, Boris; Swisher, Stephen G.; Vaporciyan, Ara; Walsh, Garrett L.; Johnson, Faye M.; Fang, Bingliang
• Is Part Of: Cancer letters. Volume 357:Issue 1(2015)
• Page Start: 179
• Page End: 185
• Publication Date: 2015-02-01
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2014.11.024
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">23 PDXs from lung cancer and their primary tumors were sequenced by exome sequencing analysis on 202 cancer-related genes.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Numbers of primary tumors with mutations in <italic>TP53, KRAS, PI3KCA, ALK, STK11, </italic> and <italic>EGFR</italic> were 10, 5, 4, 4, 3, and 2, respectively.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Other genes with mutations in ≥3 tumors were <italic>MLL3, SETD2, ATM, ARID1A, CRIPAK, HGF, BAI3, EP300, KDR, PDGRRA</italic> and <italic>RUNX1</italic>.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">93% of mutations detected in the primary tumors were also detected in their corresponding PDXs.</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030">Some mutations had higher allele frequencies in the PDXs than in the primary tumors, suggesting tumor cell enrichment in PDXs.</p> </list-item> </list> </p> </sec> </abstract>