Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer. Issue 1 (1st February 2015) - Hao, Chuncheng
Highlights 23 PDXs from lung cancer and their primary tumors were sequenced by exome sequencing analysis on 202 cancer-related genes. Numbers of primary tumors with mutations in TP53, KRAS, PI3KCA, ALK, STK11, and EGFR were 10, 5, 4, 4, 3, and 2, respectively. Other genes with mutations in ≥3 tumors were MLL3, SETD2, ATM, ARID1A, CRIPAK, HGF, BAI3, EP300, KDR, PDGRRA and RUNX1. 93% of mutations detected in the primary tumors were also detected in their corresponding PDXs. Some mutations had higher allele frequencies in the PDXs than in the primary tumors, suggesting tumor cell enrichment in PDXs.