Adjuvant system AS02V enhances humoral and cellular immune responses to pneumococcal protein PhtD vaccine in healthy young and older adults: Randomised, controlled trials. Issue 4 (15th January 2015)

• Record Type: Journal Article
• Authors: Leroux-Roels, Isabel; Devaster, Jeanne-Marie; Leroux-Roels, Geert; Verlant, Vincent; Henckaerts, Isabelle; Moris, Philippe; Hermand, Philippe; Van Belle, Pascale; Poolman, Jan T.; Vandepapelière, Pierre; Horsmans, Yves
• Is Part Of: Vaccine. Volume 33:Issue 4(2015)
• Page Start: 577
• Page End: 584
• Publication Date: 2015-01-15
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2013.10.052
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Pneumococcal protein vaccines potentially provide serotype-independent protection.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">A PhtD vaccine with or without adjuvant was assessed in healthy young/older adults.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">All formulations had an acceptable reactogenicity profile, without safety concerns.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">PhtD/AS02_V induced PhtD-specific antibody, CD4 T cell and memory B cell responses.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Immune responses in older adults were partly restored with AS02_V adjuvant system.</p> </list-item> </list> </p> </sec> </abstract>