Adjuvant system AS02V enhances humoral and cellular immune responses to pneumococcal protein PhtD vaccine in healthy young and older adults: Randomised, controlled trials. Issue 4 (15th January 2015) - Leroux-Roels, Isabel
Highlights Pneumococcal protein vaccines potentially provide serotype-independent protection. A PhtD vaccine with or without adjuvant was assessed in healthy young/older adults. All formulations had an acceptable reactogenicity profile, without safety concerns. PhtD/AS02V induced PhtD-specific antibody, CD4 T cell and memory B cell responses. Immune responses in older adults were partly restored with AS02V adjuvant system.