17-beta estradiol inhibits oxidative stress-induced accumulation of AIF into nucleolus and PARP1-dependent cell death via estrogen receptor alpha. Issue 1 (5th January 2015)

• Record Type: Journal Article
• Authors: Batnasan, Enkhzaya; Wang, Ruoxi; Wen, Jitao; Ke, Yueshuang; Li, Xiaoxue; Bohio, Ameer Ali; Zeng, Xianlu; Huo, Hongliang; Han, Liping; Boldogh, Istvan; Ba, Xueqing
• Is Part Of: Toxicology letters. Volume 232:Issue 1(2015)
• Page Start: 1
• Page End: 9
• Publication Date: 2015-01-05
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2014.09.024
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0065"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Estrogen inhibits H₂O₂-induced PARP1 activation and nuclear fragmentation.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Estrogen blocks H₂O₂-induced AIF translocation to nucleoli.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Estrogen protects MCF-7 cells from H₂O₂-induced cell death.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Estrogen receptor alpha mediates the protective role of estrogen.</p> </list-item> </list> </p> </sec> </abstract>