Combined effects of current-smoking and the aldehyde dehydrogenase 2*2 allele on the risk of myocardial infarction in Japanese patients. Issue 1 (5th January 2015)

• Record Type: Journal Article
• Authors: Morita, Kazunori; Miyazaki, Hiroko; Saruwatari, Junji; Oniki, Kentaro; Kumagae, Naoki; Tanaka, Takahiro; Kajiwara, Ayami; Otake, Koji; Ogata, Yasuhiro; Arima, Yuichiro; Hokimoto, Seiji; Ogawa, Hisao; Nakagawa, Kazuko
• Is Part Of: Toxicology letters. Volume 232:Issue 1(2015)
• Page Start: 221
• Page End: 225
• Publication Date: 2015-01-05
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2014.11.014
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0040"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Aldehyde dehydrogenase 2 (ALDH2) detoxifies toxic aldehydes in cigarette smoke.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Current-smoking <italic>ALDH2*2</italic> allele carriers were at risk of myocardial infarction (MI).</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Current-smoking and <italic>ALDH2*2</italic> synergistically increased the peak creatine kinase.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Current-smoking and <italic>ALDH2*2</italic> synergistically increased triglycerides in MI subjects.</p> </list-item> </list> </p> </sec> </abstract>