FGFR as potential target in the treatment of squamous non small cell lung cancer. Issue 6 (June 2015)

• Record Type: Journal Article
• Authors: Tiseo, Marcello; Gelsomino, Francesco; Alfieri, Roberta; Cavazzoni, Andrea; Bozzetti, Cecilia; De Giorgi, Anna Maria; Petronini, Pier Giorgio; Ardizzoni, Andrea
• Is Part Of: Cancer treatment reviews. Volume 41:Issue 6(2015)
• Page Start: 527
• Page End: 539
• Publication Date: 2015-06
• Subjects: Cancer -- Periodicals; Cancer -- Treatment -- Periodicals; Neoplasms -- therapy -- Periodicals; Cancer -- Périodiques; Cancer -- Traitement -- Périodiques; Cancer -- Treatment; Electronic journals; Periodicals; 616.99406
• DOI: 10.1016/j.ctrv.2015.04.011
• Languages: English
• ISSNs: 0305-7372

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0135"> <list-item id="o0515"> <label></label> <p id="p0515">Squamous lung cancers have been regarded as tumors without targetable molecular alterations.</p> </list-item> <list-item id="o0520"> <label></label> <p id="p0520">FGF/FGFR pathway deregulation is increasingly recognized across different tumors.</p> </list-item> <list-item id="o0525"> <label></label> <p id="p0525">FGF/FGFR pathway is one of the most promising druggable target in squamous lung cancers.</p> </list-item> <list-item id="o0530"> <label></label> <p id="p0530">FGFR amplifications, mutations, translocations are the most frequent mechanisms of activation.</p> </list-item> <list-item id="o0535"> <label></label> <p id="p0535">mAbs, ligand traps, TKIs directed versus FGF/FGFR are in development in lung tumor.</p> </list-item> </list> </p> </sec> </abstract>