FGFR as potential target in the treatment of squamous non small cell lung cancer. Issue 6 (June 2015) - Tiseo, Marcello
Highlights Squamous lung cancers have been regarded as tumors without targetable molecular alterations. FGF/FGFR pathway deregulation is increasingly recognized across different tumors. FGF/FGFR pathway is one of the most promising druggable target in squamous lung cancers. FGFR amplifications, mutations, translocations are the most frequent mechanisms of activation. mAbs, ligand traps, TKIs directed versus FGF/FGFR are in development in lung tumor.