Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts. Issue 1 (February 2015)

• Record Type: Journal Article
• Authors: Krais, Annette M.; Mühlbauer, Karl-Rudolf; Kucab, Jill E.; Chinbuah, Helena; Cornelius, Michael G.; Wei, Quan-Xiang; Hollstein, Monica; Phillips, David H.; Arlt, Volker M.; Schmeiser, Heinz H.
• Is Part Of: Toxicology in vitro. Volume 29:Issue 1(2015)
• Page Start: 34
• Page End: 43
• Publication Date: 2015-02
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2014.09.004
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st090">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0170">ES cells and MEF have the metabolic competence to activate environmental carcinogens.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0175">Carcinogen-induced genotoxicity in MEFs is higher than in ES cells.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0180">MEFs have higher metabolic capacity than ES cells.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0185">Metabolic capacity depends on the carcinogen studied.</p> </list-item> </list> </p> </sec> </abstract>