Vesicular disruption of lysosomal targeting organometallic polyarginine bioconjugates1. Issue 2 (11th March 2015)

• Record Type: Journal Article
• Authors: Gross, Annika; Alborzinia, Hamed; Piantavigna, Stefania; Martin, Lisandra L.; Wölfl, Stefan; Metzler-Nolte, Nils
• Is Part Of: Metallomics. Volume 7:Issue 2(2015:Feb.)
• Page Start: 371
• Page End: 384
• Publication Date: 2015-03-11
• Subjects: Metals -- Physiological effect -- Periodicals; 572.51
• DOI: 10.1039/c4mt00255e
• Languages: English
• ISSNs: 1756-5901

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj40xfj59" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />Targeting of lysosomes is an interesting, novel pathway for cancer therapy. in this work, novel metallocene derivatives (of ferrocene and ruthenocene) of a cell penetrating polyarginine peptide are presented as lysosomal membrane permeabilization (LMP) agents and their localization and biological activity is investigated in detail.</p> </abstract>