Intracellular free fatty acid upholds β‐cell glucose competence: The role of peroxisome proliferator‐activated receptor δ and mitochondrial metabolism. Issue 2 (15th July 2014)

• Record Type: Journal Article
• Authors: Takei, Masahiro; Komatsu, Mitsuhisa; Aizawa, Toru
• Is Part Of: Journal of diabetes investigation. Volume 6:Issue 2(2015:Apr.)
• Page Start: 133
• Page End: 136
• Publication Date: 2014-07-15
• Subjects: Diabetes -- Periodicals; Diabetes -- Research -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462005
• DOI: 10.1111/jdi.12257
• Languages: English
• ISSNs: 2040-1116

Abstract

<abstract abstract-type="graphical" id="jdi12257-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Tang <italic>et al</italic>. identified a novel downstream signaling pathway for intracellular FFA in pancreatic beta cells: activation of peroxisome proliferator‐activated receptor δ (PPARδ) followed by enhanced mitochondrial metabolism. This was accomplished by using beta‐cell specific desnutrin/ATGL knockout (desnutrin βKO) mice. <boxed-text content-type="graphic" id="jdi12257-blkfxd-0001" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgj430j2dg" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>