KSHV‐TK is a tyrosine kinase that disrupts focal adhesions and induces Rho‐mediated cell contraction. (3rd December 2014)

• Record Type: Journal Article
• Authors: Gill, Michael B; Turner, Rachel; Stevenson, Philip G; Way, Michael
• Is Part Of: EMBO journal. Volume 34:Number 4(2015)
• Page Start: 448
• Page End: 465
• Publication Date: 2014-12-03
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.201490358
• Languages: English
• ISSNs: 0261-4189

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="embj201490358-abs-0003"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Gammaherpesviruses are known to encode very inefficient thymidine kinases. KSHV thymidine kinase is actually a tyrosine kinase that induces focal adhesion disassembly via its interaction with known regulators including members of the Crk‐related family of adaptor proteins. <boxed-text content-type="graphic" id="embj201490358-blkfxd-0002" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh3wc6mv02" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>