CNT Biosafety: Multiwall Carbon Nanotubes Directly Promote Fibroblast–Myofibroblast and Epithelial–Mesenchymal Transitions through the Activation of the TGF‐β/Smad Signaling Pathway (Small 4/2015). Issue 4 (January 2015)

• Record Type: Journal Article
• Authors: Wang, Peng; Wang, Yue; Nie, Xin; Braïni, Céline; Bai, Ru; Chen, Chunying
• Is Part Of: Small. Volume 11:Issue 4(2015)
• Page Start: 385
• Page End: 385
• Publication Date: 2015-01
• Subjects: Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201570019
• Languages: English
• ISSNs: 1613-6810

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="smll201570019-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The underlying mechanisms demonstrated by C. Chen and co‐workers on page 446 show how multiwalled carbon nanotubes (MWCNTs) induce granuloma formation and fibrotic responses in vivo. MWCNT exposure can promote a fibroblast‐to‐myofibroblast conversion and the epithelial‐mesenchymal transition (EMT) through the activation of the TGF‐ß/Smad signaling pathway. Both of the cell transitions may play important roles in MWCNT‐induced pulmonary fibrosis. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh3jjv59s0" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>