CNT Biosafety: Multiwall Carbon Nanotubes Directly Promote Fibroblast–Myofibroblast and Epithelial–Mesenchymal Transitions through the Activation of the TGF‐β/Smad Signaling Pathway (Small 4/2015). Issue 4 (January 2015) - Wang, Peng
Abstract The underlying mechanisms demonstrated by C. Chen and co‐workers on page 446 show how multiwalled carbon nanotubes (MWCNTs) induce granuloma formation and fibrotic responses in vivo. MWCNT exposure can promote a fibroblast‐to‐myofibroblast conversion and the epithelial‐mesenchymal transition (EMT) through the activation of the TGF‐ß/Smad signaling pathway. Both of the cell transitions may play important roles in MWCNT‐induced pulmonary fibrosis.