Non‐Viral Gene Delivery via Membrane‐Penetrating, Mannose‐Targeting Supramolecular Self‐Assembled Nanocomplexes. (18th February 2013)

• Record Type: Journal Article
• Authors: Yin, Lichen; Song, Ziyuan; Kim, Kyung Hoon; Zheng, Nan; Gabrielson, Nathan P.; Cheng, Jianjun
• Is Part Of: Advanced materials. Volume 25:Number 22(2013)
• Page Start: 3063
• Page End: 3070
• Publication Date: 2013-02-18
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201205088
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Supramolecular self‐assembled nanocomplexes (SSANs)</bold> capable of mannose receptor‐mediated endocytosis and permeable to cellular and endosomal membranes are developed via the assembly of multiple rationally designed, function‐specific materials. As a unique non‐viral gene delivery vector, SSANs outperform commercial transfection reagents, including LPF2000, PEI, and jetPEI, by up to 2 orders of magnitude. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg21kq62g5" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>