Non‐Viral Gene Delivery via Membrane‐Penetrating, Mannose‐Targeting Supramolecular Self‐Assembled Nanocomplexes. (18th February 2013) - Yin, Lichen
Abstract Supramolecular self‐assembled nanocomplexes (SSANs) capable of mannose receptor‐mediated endocytosis and permeable to cellular and endosomal membranes are developed via the assembly of multiple rationally designed, function‐specific materials. As a unique non‐viral gene delivery vector, SSANs outperform commercial transfection reagents, including LPF2000, PEI, and jetPEI, by up to 2 orders of magnitude.