Anti‐obesogenic effects of calcium prevent changes in the GLP‐1 profile in adult rats primed by early weaning. Issue 4 (23rd February 2015)

• Record Type: Journal Article
• Authors: Quitete, Fernanda Torres; Nobre, Jessica Lopes; Peixoto‐Silva, Nayara; de Moura, Egberto Gaspar; Lisboa, Patricia Cristina; de Oliveira, Elaine
• Is Part Of: Molecular nutrition & food research. Volume 59:Issue 4(2015:Apr.)
• Page Start: 773
• Page End: 783
• Publication Date: 2015-02-23
• Subjects: Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.201400666
• Languages: English
• ISSNs: 1613-4125

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mnfr2331-sec-0010" sec-type="section"> <title>Scope</title> <p>Gut peptides regulate appetite and adipogenesis. Early weaning (EW) leads to later development of obesity that can be prevented by calcium supplementation. We evaluated gut peptides that may have a role in the establishment of this dysfunction.</p> </sec> <sec id="mnfr2331-sec-0020" sec-type="section"> <title>Methods and results</title> <p>At birth, lactating Wistar rats were separated in: EW, lactating rats involved with a bandage interrupting the lactation during the last 4 days of standard lactation, and C (control) dams whose pups had free access to milk during throughout lactation. At 120 days old, half of EW group received calcium supplementation (EWCa); EW and C received standard diet. At 21 days old, EW presented higher glucagon‐like peptide 1 (GLP‐1) in plasma and glucagon‐like peptide 1 receptor (GLP1‐R) in adipose tissue and hypothalamus, but lower GLP‐1 and GLP1‐R in the gut. At 180 days old, GLP‐1 response to food intake was blunted in EW and restored by calcium. GLP‐1 in the gut was lower in EW and its receptor was lower in adipose tissue, and GLP1‐R was higher in the gut of calcium EW group.</p> </sec> <sec id="mnfr2331-sec-0030" sec-type="section"> <title>Conclusion</title> <p>Thus, EW had short‐ and long‐term effects upon GLP‐1 profile, which may have contributed to obesity development, hyperphagia, and insulin resistance due to its adipogenic and appetite control roles. Calcium supplementation was able to prevent most of the changes in GLP‐1 caused by EW.</p> </sec> </abstract>