A new [2H]‐labelled α‐trichloroimidate glucuronic ester for the synthesis of deuterated drug conjugates. (22nd October 2014)

• Record Type: Journal Article
• Authors: Heinkele, Georg; Geditz, Mirjam C. K.; Ganchev, Boian; Kerb, Reinhold; Hofmann, Ute; Mürdter, Thomas E.
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 57:Number 12(2014)
• Page Start: 699
• Page End: 703
• Publication Date: 2014-10-22
• Subjects: Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3243
• Languages: English
• ISSNs: 0362-4803

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>A new reaction pathway for the synthesis of a [²H]‐labelled trichloroacetimidate precursor for the preparation of glucuronides is described. Therewith, stable isotope‐labelled drug glucuronides become accessible on a preparative scale, which can further be used as internal standards for quantitative analysis.</p> </abstract>