IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms. Issue 7 (24th June 2014)

• Record Type: Journal Article
• Authors: Wang, Jing; Lindholt, Jes S; Sukhova, Galina K; Shi, Michael A; Xia, Mingcan; Chen, Han; Xiang, Meixiang; He, Aina; Wang, Yi; Xiong, Na; Libby, Peter; Wang, Jian‐An; Shi, Guo‐Ping
• Is Part Of: EMBO molecular medicine. Volume 6:Issue 7(2014:Jul.)
• Page Start: 952
• Page End: 969
• Publication Date: 2014-06-24
• Subjects: Molecular biology -- Periodicals; Medical genetics -- Periodicals; Pathology, Molecular -- Periodicals; 616.04205
• DOI: 10.15252/emmm.201303811
• Languages: English
• ISSNs: 1757-4676

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="emmm201303811-abs-0003"> <title> <x xml:space="preserve">Abstract</x> </title> <p>This study demonstrates the pathologic role of IgE and its high affinity receptor FcεR1 in AAAs by activating MCs, macrophages but also CD4 and CD8 T cells and suggests anti‐IgE antibodies as future putative therapeutics for treatment. <boxed-text content-type="graphic" id="emmm201303811-blkfxd-0002" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh12vftxzk" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>