Excess α‐tocopherol decreases extrahepatic phylloquinone in phylloquinone‐fed rats but not menaquinone‐4 in menaquinone‐4‐fed rats. Issue 8 (16th April 2014)

• Record Type: Journal Article
• Authors: Hanzawa, Fumiaki; Sakuma, Eri; Nomura, Saki; Uchida, Tomono; Oda, Hiroaki; Ikeda, Saiko; Traber, Maret G.
• Is Part Of: Molecular nutrition & food research. Volume 58:Issue 8(2014:Aug.)
• Page Start: 1601
• Page End: 1609
• Publication Date: 2014-04-16
• Subjects: Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.201300710
• Languages: English
• ISSNs: 1613-4125

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mnfr2190-sec-0010" sec-type="section"> <title>Scope</title> <p>The effects of vitamin E on vitamin K metabolism were elucidated by comparing the effect of tocopherol intake on vitamin K concentrations in rats fed phylloquinone (PK) or menaquinone (MK)‐4.</p> </sec> <sec id="mnfr2190-sec-0020" sec-type="section"> <title>Methods and results</title> <p>Initially, the dietary effect of <italic>RRR</italic>‐α‐tocopherol, but not <italic>RRR</italic>‐γ‐tocopherol, in decreasing extrahepatic PK concentrations was confirmed. Subsequently, rats were fed a PK or MK‐4‐containing diet (0.75 mg/kg) with <italic>RRR</italic>‐α‐tocopherol (0, 10, 50, or 500 mg/kg) for 6 weeks. In rats fed PK, α‐tocopherol consumption decreased PK in kidney, lung, heart, muscle, testis, and brain but not in serum and liver. However, in rats fed MK‐4, α‐tocopherol consumption did not decrease MK‐4 in serum and tissues. Finally, vitamin K‐ and E‐depleted rats were administered PK or MK‐4 (0.2 mg) with <italic>RRR</italic>‐α‐tocopherol (0, 1, or 10 mg) by gavage. After PK administration, α‐tocopherol was observed to decrease PK in kidney, adrenal gland, lung, testis, and brain but not in serum and liver, whereas, after MK‐4 administration, α‐tocopherol did not affect MK‐4 in serum and tissues.</p> </sec> <sec id="mnfr2190-sec-0030" sec-type="section"> <title>Conclusion</title> <p>Excess α‐tocopherol decreased extrahepatic PK in rats fed PK but not MK‐4 in rats fed MK‐4.</p> </sec> </abstract>