Catalytic Asymmetric α‐Hydroxyamination of Carbonyls with N‐Hydroxycarbamates Becomes Greener. Issue 7 (2nd June 2014)

• Record Type: Journal Article
• Authors: Yu, Chenguang; Song, Aiguo; Zhang, Fang; Wang, Wei
• Is Part Of: ChemCatChem. Volume 6:Issue 7(2014:Jul.)
• Page Start: 1863
• Page End: 1865
• Publication Date: 2014-06-02
• Subjects: Catalysis -- Periodicals; 541.39505
• DOI: 10.1002/cctc.201402121
• Languages: English
• ISSNs: 1867-3880

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The power of two:</bold> A highly enantio‐ and regioselective aminocatalytic and Lewis acid catalyzed α‐hydroxyamination of β‐keto esters and 1, 3‐diketones with <italic>N</italic>‐hydroxycarbamates is realized in "one‐pot" under aerobic conditions. The powerful dual catalysis strategy opens opportunities for developing new efficient organic transformations. Cbz=Benzyloxycarbonyl, Boc=<italic>tert</italic>‐butoxycarbonyl.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pghr2bvrdt" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>