Hibiscus sabdariffa extract lowers blood pressure and improves endothelial function. Issue 6 (24th February 2014)

• Record Type: Journal Article
• Authors: Joven, Jorge; March, Isabel; Espinel, Eugenia; Fernández‐Arroyo, Salvador; Rodríguez‐Gallego, Esther; Aragonès, Gerard; Beltrán‐Debón, Raúl; Alonso‐Villaverde, Carlos; Rios, Lidia; Martin‐Paredero, Vicente; Menendez, Javier A.; Micol, Vicente; Segura‐Carretero, Antonio; Camps, Jordi
• Is Part Of: Molecular nutrition & food research. Volume 58:Issue 6(2014:Jun.)
• Page Start: 1374
• Page End: 1378
• Publication Date: 2014-02-24
• Subjects: Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.201300774
• Languages: English
• ISSNs: 1613-4125

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Polyphenols from <italic>Hibiscus sabdariffa</italic> calices were administered to patients with metabolic syndrome (125 mg/kg/day for 4 wk, <italic>n</italic> = 31) and spontaneously hypertensive rats (125 or 60 mg/kg in a single dose or daily for 1 wk, <italic>n</italic> = 8 for each experimental group). The <italic>H. sabdariffa</italic> extract improved metabolism, displayed potent anti‐inflammatory and antioxidant activities, and significantly reduced blood pressure in both humans and rats. Diuresis and inhibition of the angiotensin I‐converting enzyme were found to be less important mechanisms than those related to the antioxidant, anti‐inflammatory, and endothelium‐dependent effects to explain the beneficial actions. Notably, polyphenols induced a favorable endothelial response that should be considered in the management of metabolic cardiovascular risks.</p> </abstract>