Dietary α‐mangostin, a xanthone from mangosteen fruit, exacerbates experimental colitis and promotes dysbiosis in mice. Issue 6 (17th February 2014)

• Record Type: Journal Article
• Authors: Gutierrez‐Orozco, Fabiola; Thomas‐Ahner, Jennifer M.; Berman‐Booty, Lisa D.; Galley, Jeffrey D.; Chitchumroonchokchai, Chureeporn; Mace, Thomas; Suksamrarn, Sunit; Bailey, Michael T.; Clinton, Steven K.; Lesinski, Gregory B.; Failla, Mark L.
• Is Part Of: Molecular nutrition & food research. Volume 58:Issue 6(2014:Jun.)
• Page Start: 1226
• Page End: 1238
• Publication Date: 2014-02-17
• Subjects: Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.201300771
• Languages: English
• ISSNs: 1613-4125

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mnfr2175-sec-0010" sec-type="section"> <title>Scope</title> <p>Ulcerative colitis (UC) is a chronic inflammatory disease of the colon. α‐Mangostin (α‐MG), the most abundant xanthone in mangosteen fruit, exerts anti‐inflammatory and antibacterial activities in vitro. We evaluated the impact of dietary α‐MG on murine experimental colitis and on the gut microbiota of healthy mice.</p> </sec> <sec id="mnfr2175-sec-0020" sec-type="section"> <title>Methods and results</title> <p>Colitis was induced in C57BL/6J mice by administration of dextran sulfate sodium (DSS). Mice were fed control diet or diet with α‐MG (0.1%). α‐MG exacerbated the pathology of DSS‐induced colitis. Mice fed diet with α‐MG had greater colonic inflammation and injury, as well as greater infiltration of CD3<sup>+</sup> and F4/80<sup>+</sup> cells, and colonic myeloperoxidase, than controls. Serum levels of granulocyte colony‐stimulating factor, IL‐6, and serum amyloid A were also greater in α‐MG‐fed animals than in controls. The colonic and cecal microbiota of healthy mice fed α‐MG but no DSS shifted to an increased abundance of Proteobacteria and decreased abundance of Firmicutes and Bacteroidetes, a profile similar to that found in human UC.</p> </sec> <sec id="mnfr2175-sec-0030" sec-type="section"> <title>Conclusion</title> <p>α‐MG exacerbated colonic pathology during DSS‐induced colitis. These effects may be associated with an induction of intestinal dysbiosis by α‐MG. Our results suggest that the use of α‐MG‐containing supplements by patients with UC may have unintentional risk.</p> </sec> </abstract>