Copper‐Catalyzed Trifluoromethylation–Cyclization of Enynes: Highly Regioselective Construction of Trifluoromethylated Carbocycles and Heterocycles. Issue 43 (23rd September 2013)

• Record Type: Journal Article
• Authors: Gao, Pin; Yan, Xiao‐Biao; Tao, Tao; Yang, Fan; He, Ting; Song, Xian‐Rong; Liu, Xue‐Yuan; Liang, Yong‐Min
• Is Part Of: Chemistry. Volume 19:Issue 43(2013)
• Page Start: 14420
• Page End: 14424
• Publication Date: 2013-09-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201303025
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Regioselective trifluoromethylation–cyclization</bold>: A method for copper‐catalyzed trifluoromethylation–cyclization of simple enynes using the CC triple bond as a nucleophile is reported for the first time (see scheme). The reaction proceeds efficiently in a highly regioselective manner to give various 5‐ or 6<italic>‐exo‐dig</italic> carbocycles and heterocycles in moderate to high yields.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t3tpdnt" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>