Inside Cover: Bicyclic Peptide Inhibitor of Urokinase‐Type Plasminogen Activator: Mode of Action (ChemBioChem 16/2013). Issue 16 (25th October 2013)

• Record Type: Journal Article
• Authors: Roodbeen, Renée; Paaske, Berit; Jiang, Longguang; Jensen, Jan K.; Christensen, Anni; Nielsen, Jakob T.; Huang, Mingdong; Mulder, Frans A. A.; Nielsen, Niels Chr.; Andreasen, Peter A.; Jensen, Knud J.
• Is Part Of: Chembiochem. Volume 14:Issue 16(2013)
• Page Start: 2062
• Page End: 2062
• Publication Date: 2013-10-25
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201390059
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The inside cover picture shows</bold> the binding of a rationally designed bicyclic peptide inhibitor to the serine protease urokinase‐type plasminogen activator (uPA). On <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">p. 2179 ff., </ext-link> K. J. Jensen et al. describe how a monocyclic peptide was transformed into a bicyclic peptide without loss of inhibitory properties but, rewardingly, with a reduced loss of entropy upon binding.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t78rmr1" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>