Inside Cover: Bicyclic Peptide Inhibitor of Urokinase‐Type Plasminogen Activator: Mode of Action (ChemBioChem 16/2013). Issue 16 (25th October 2013) - Roodbeen, Renée
Abstract The inside cover picture shows the binding of a rationally designed bicyclic peptide inhibitor to the serine protease urokinase‐type plasminogen activator (uPA). On p. 2179 ff., K. J. Jensen et al. describe how a monocyclic peptide was transformed into a bicyclic peptide without loss of inhibitory properties but, rewardingly, with a reduced loss of entropy upon binding.