Formal Synthesis of (±)‐Morphine. Issue 6 (18th March 2013)

• Record Type: Journal Article
• Authors: Li, Jing; Liu, Guo‐Liang; Zhao, Xian‐He; Du, Ji‐Yuan; Qu, Hu; Chu, Wen‐Dao; Ding, Ming; Jin, Cong‐Yang; Wei, Meng‐Xue; Fan, Chun‐An
• Is Part Of: Chemistry, an Asian journal. Volume 8:Issue 6(2013:Jun.)
• Page Start: 1105
• Page End: 1109
• Publication Date: 2013-03-18
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201300139
• Languages: English
• ISSNs: 1861-4728

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The pain ends here</bold>: A novel synthetic strategy for the construction of (±)‐morphine rings B and E was developed, in which SmI₂‐promoted reductive coupling/desulfurization and tandem alcoholysis/oxa‐Michael addition featured as the key steps for the assembly of the C9C14 and C5O bonds, respectively. Asymmetric tandem alcoholysis/oxa‐Michael addition was also feasible for the enantiocontrolled synthesis of morphine.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t78fg57" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>