Formal Synthesis of (±)‐Morphine. Issue 6 (18th March 2013) - Li, Jing
Abstract The pain ends here: A novel synthetic strategy for the construction of (±)‐morphine rings B and E was developed, in which SmI2‐promoted reductive coupling/desulfurization and tandem alcoholysis/oxa‐Michael addition featured as the key steps for the assembly of the C9C14 and C5O bonds, respectively. Asymmetric tandem alcoholysis/oxa‐Michael addition was also feasible for the enantiocontrolled synthesis of morphine.