Back Cover: Rhodium‐Catalyzed Ketone Methylation Using Methanol Under Mild Conditions: Formation of α‐Branched Products (Angew. Chem. Int. Ed. 3/2014). Issue 3 (13th January 2014)

• Record Type: Journal Article
• Authors: Chan, Louis K. M.; Poole, Darren L.; Shen, Di; Healy, Mark P.; Donohoe, Timothy J.
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 3(2014)
• Page Start: 892
• Page End: 892
• Publication Date: 2014-01-13
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201310758
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The <italic>α</italic>‐methylation of ketones using methanol as the carbon source is described in the Communication by T. J. Donohoe et al. on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 761 ff.</ext-link> The reaction of a carbonyl compound, a base, a catalytic amount of rhodium, and methanol in an atmosphere of oxygen allows the alkylation to proceed at 65 °C. The use of an iridium/rhodium catalyst combination facilitates a double cycle of alkylation reactions, which transforms methyl ketones into more highly substituted compounds.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4sm9w3z4" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>