Back Cover: Rhodium‐Catalyzed Ketone Methylation Using Methanol Under Mild Conditions: Formation of α‐Branched Products (Angew. Chem. Int. Ed. 3/2014). Issue 3 (13th January 2014) - Chan, Louis K. M.
Abstract The α‐methylation of ketones using methanol as the carbon source is described in the Communication by T. J. Donohoe et al. on page 761 ff. The reaction of a carbonyl compound, a base, a catalytic amount of rhodium, and methanol in an atmosphere of oxygen allows the alkylation to proceed at 65 °C. The use of an iridium/rhodium catalyst combination facilitates a double cycle of alkylation reactions, which transforms methyl ketones into more highly substituted compounds.