Immobilization of Actively Thromboresistant Assemblies on Sterile Blood‐Contacting Surfaces. Issue 1 (21st June 2013)

• Record Type: Journal Article
• Authors: Qu, Zheng; Krishnamurthy, Venkat; Haller, Carolyn A.; Dorr, Brent M.; Marzec, Ulla M.; Hurst, Sawan; Hinds, Monica T.; Hanson, Stephen R.; Liu, David R.; Chaikof, Elliot L.
• Is Part Of: Advanced healthcare materials. Volume 3:Issue 1(2014:Jan.)
• Page Start: 30
• Page End: 35
• Publication Date: 2013-06-21
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201300110
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Rapid one‐step modification of thrombomodulin with alkylamine derivatives such as azide, biotin, and PEG</bold> is achieved using an evolved sortase (eSrtA) mutant. The feasibility of a point‐of‐care scheme is demonstrated herein to site‐specifically immobilize azido‐thrombomodulin on sterilized commercial ePTFE vascular grafts, which exhibit superior thromboresistance compared with commercial heparin‐coated grafts in a primate model of acute graft thrombosis. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4sm1cnjz" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>