Nanoparticle‐Programmed Self‐Destructive Neural Stem Cells for Glioblastoma Targeting and Therapy. Issue 24 (21st July 2013)

• Record Type: Journal Article
• Authors: Cheng, Yu; Morshed, Ramin; Cheng, Shih‐Hsun; Tobias, Alex; Auffinger, Brenda; Wainwright, Derek A.; Zhang, Lingjiao; Yunis, Catherine; Han, Yu; Chen, Chin‐Tu; Lo, Leu‐Wei; Aboody, Karen S.; Ahmed, Atique U.; Lesniak, Maciej S.
• Is Part Of: Small. Volume 9:Issue 24(2013:Dec.)
• Page Start: 4123
• Page End: 4129
• Publication Date: 2013-07-21
• Subjects: Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201301111
• Languages: English
• ISSNs: 1613-6810

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A 3‐step glioblastoma‐tropic delivery and therapy method using nanoparticle programmed self‐destructive neural stem cells (NSCs)</bold> is demonstrated in vivo: 1) FDA‐approved NSCs for clinical trials are loaded with pH‐sensitive MSN‐Dox; 2) the nanoparticle conjugates provide a delayed drug‐releasing mechanism and allow for NSC migration towards a distant tumor site; 3) NSCs eventually undergo cell death and release impregnated MSN‐Dox, which subsequently induces toxicity towards surrounding glioma cells. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t6np8dw" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>