Nanoparticle‐Programmed Self‐Destructive Neural Stem Cells for Glioblastoma Targeting and Therapy. Issue 24 (21st July 2013) - Cheng, Yu
Abstract A 3‐step glioblastoma‐tropic delivery and therapy method using nanoparticle programmed self‐destructive neural stem cells (NSCs) is demonstrated in vivo: 1) FDA‐approved NSCs for clinical trials are loaded with pH‐sensitive MSN‐Dox; 2) the nanoparticle conjugates provide a delayed drug‐releasing mechanism and allow for NSC migration towards a distant tumor site; 3) NSCs eventually undergo cell death and release impregnated MSN‐Dox, which subsequently induces toxicity towards surrounding glioma cells.