VEGF‐B‐induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart. Issue 3 (21st January 2014)

• Record Type: Journal Article
• Authors: Kivelä, Riikka; Bry, Maija; Robciuc, Marius R; Räsänen, Markus; Taavitsainen, Miia; Silvola, Johanna MU; Saraste, Antti; Hulmi, Juha J; Anisimov, Andrey; Mäyränpää, Mikko I; Lindeman, Jan H; Eklund, Lauri; Hellberg, Sanna; Hlushchuk, Ruslan; Zhuang, Zhen W; Simons, Michael; Djonov, Valentin; Knuuti, Juhani; Mervaala, Eero; Alitalo, Kari
• Is Part Of: EMBO molecular medicine. Volume 6:Issue 3(2014:Mar.)
• Page Start: 307
• Page End: 321
• Publication Date: 2014-01-21
• Subjects: Molecular biology -- Periodicals; Medical genetics -- Periodicals; Pathology, Molecular -- Periodicals; 616.04205
• DOI: 10.1002/emmm.201303147
• Languages: English
• ISSNs: 1757-4676

Abstract

<abstract abstract-type="synopsis" xml:lang="en" id="emmm201303147-abs-0002"> <title>Synopsis</title> <p> <boxed-text content-type="graphic" id="emmm201303147-blkfxd-0001" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4st018xj" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> <p>Transgenic expression of VEGF‐B in the rat heart leads to expansion of the coronary arterial tree and an increase in functional coronary reserve, accompanied by a shift in myocardial metabolism from fatty acid to glucose utilization.</p> <p> <list id="emmm201303147-list-0001" list-type="bullet"> <list-item> <p>VEGF‐B‐induced coronary artery growth protects the heart from ischemic damage</p> </list-item> <list-item> <p>Cardiac hypertrophy in VEGF‐B transgenic rats is physiological even in old age</p> </list-item> <list-item> <p>AAV‐VEGF‐B gene transfer to adult rats phenocopies the VEGF‐B transgenic rat heart</p> </list-item> <list-item> <p>Glucose uptake is increased and expression of fatty acid oxidation genes decreased in the VEGF‐B transgenic hearts</p> </list-item> <list-item> <p>VEGF‐B increases VEGF signaling via VEGFR‐2</p> </list-item> </list> </p> </abstract>