VEGF‐B‐induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart. Issue 3 (21st January 2014) - Kivelä, Riikka
Synopsis Transgenic expression of VEGF‐B in the rat heart leads to expansion of the coronary arterial tree and an increase in functional coronary reserve, accompanied by a shift in myocardial metabolism from fatty acid to glucose utilization. VEGF‐B‐induced coronary artery growth protects the heart from ischemic damage Cardiac hypertrophy in VEGF‐B transgenic rats is physiological even in old age AAV‐VEGF‐B gene transfer to adult rats phenocopies the VEGF‐B transgenic rat heart Glucose uptake is increased and expression of fatty acid oxidation genes decreased in the VEGF‐B transgenic hearts VEGF‐B increases VEGF signaling via VEGFR‐2