Inside Cover: A Chemical Tool for In Vitro and In Vivo Precipitation of Lysine Methyltransferase G9a (ChemMedChem 3/2014). Issue 3 (March 2014)

• Record Type: Journal Article
• Authors: Konze, Kyle D.; Pattenden, Samantha G.; Liu, Feng; Barsyte‐Lovejoy, Dalia; Li, Fengling; Simon, Jeremy M.; Davis, Ian J.; Vedadi, Masoud; Jin, Jian
• Is Part Of: ChemMedChem. Volume 9:Issue 3(2014:Mar.)
• Page Start: 414
• Page End: 414
• Publication Date: 2014-03
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201490006
• Languages: English
• ISSNs: 1860-7179

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The inside cover picture shows</bold> chem‐ChIP, a method to examine occupancy of the lysine methyltranferase G9a on chromatin. UNC0965 (green) bridges streptavidin‐coupled magnetic beads (blue and yellow) and G9a (magenta). UNC0965 is cell permeable, which gives chem‐ChIP a distinct advantage over traditional in vitro antibody ChIP. For further details, see the Communication by Jian Jin et al. on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">p. 549 ff.</ext-link><boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4ss7jww8" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>