Inside Cover: Sigma‐2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity (ChemMedChem 12/2013). Issue 12 (December 2013)

• Record Type: Journal Article
• Authors: Niso, Mauro; Abate, Carmen; Contino, Marialessandra; Ferorelli, Savina; Azzariti, Amalia; Perrone, Roberto; Colabufo, Nicola Antonio; Berardi, Francesco
• Is Part Of: ChemMedChem. Volume 8:Issue 12(2013:Dec.)
• Page Start: 1898
• Page End: 1898
• Publication Date: 2013-12
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201390051
• Languages: English
• ISSNs: 1860-7179

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The inside cover picture shows</bold> a carbazole (compd <bold>25</bold> in the article) interacting with both P‐glycoprotein (P‐gp) and σ₂ receptors. Through these combined activities, a futile ATP cycle is activated and reactive oxygen species (ROS) are generated. Enhanced antiproliferative effects were observed in drug‐resistant over standard MCF7 cells. This phenomenon, termed collateral sensitivity, is under study in multidrug‐ resistant tumors, and mixed σ₂ agonists/P‐gp substrates are promising for their treatment. For more details, see the Full Paper by Carmen Abate et al. on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">p. 2026 ff.</ext-link><boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t7ncb1x" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>