Inside Cover: Sigma‐2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity (ChemMedChem 12/2013). Issue 12 (December 2013) - Niso, Mauro
Abstract The inside cover picture shows a carbazole (compd 25 in the article) interacting with both P‐glycoprotein (P‐gp) and σ2 receptors. Through these combined activities, a futile ATP cycle is activated and reactive oxygen species (ROS) are generated. Enhanced antiproliferative effects were observed in drug‐resistant over standard MCF7 cells. This phenomenon, termed collateral sensitivity, is under study in multidrug‐ resistant tumors, and mixed σ2 agonists/P‐gp substrates are promising for their treatment. For more details, see the Full Paper by Carmen Abate et al. on p. 2026 ff.