Synthesis and Structure–Activity Relationship Studies of Quinoxaline Derivatives as Aldose Reductase Inhibitors. Issue 12 (2nd October 2013)

• Record Type: Journal Article
• Authors: Wu, Bobin; Yang, Yanchun; Qin, Xiangyu; Zhang, Shuzhen; Jing, Chaojun; Zhu, Changjin; Ma, Bing
• Is Part Of: ChemMedChem. Volume 8:Issue 12(2013:Dec.)
• Page Start: 1913
• Page End: 1917
• Publication Date: 2013-10-02
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201300324
• Languages: English
• ISSNs: 1860-7179

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>ARIs for diabetes:</bold> A series of 2‐(3‐benzyl‐2‐oxoquinoxalin‐1(2<italic>H</italic>)‐yl)acetic acid derivatives were designed and synthesized as inhibitors of aldose reductase (AR), a novel target for the treatment of diabetes complications. Most of the derivatives proved to be potent and selective, with IC₅₀ values in the low nanomolar to micromolar range.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t7nc764" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>