Synthesis and Structure–Activity Relationship Studies of Quinoxaline Derivatives as Aldose Reductase Inhibitors. Issue 12 (2nd October 2013) - Wu, Bobin
Abstract ARIs for diabetes: A series of 2‐(3‐benzyl‐2‐oxoquinoxalin‐1(2H)‐yl)acetic acid derivatives were designed and synthesized as inhibitors of aldose reductase (AR), a novel target for the treatment of diabetes complications. Most of the derivatives proved to be potent and selective, with IC50 values in the low nanomolar to micromolar range.