Mechanical Carbohydrate Sensors Based on Soft Hydrogel Particles1. Issue 23 (24th April 2013)

• Record Type: Journal Article
• Authors: Pussak, Daniel; Ponader, Daniela; Mosca, Simone; Ruiz, Salomé Vargas; Hartmann, Laura; Schmidt, Stephan
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 23(2013)
• Page Start: 6084
• Page End: 6087
• Publication Date: 2013-04-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201300469
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Elastic sensors</bold>: A simple method is presented for the measurement of specific biomolecular interactions with soft colloidal hydrogel particles (SCPs) as sensors. Carbohydrate/lectin interactions (see picture; green: carbohydrate molecules) were studied by optical detection of the mechanical deformation of the particles on a lectin surface. The affinity of various carbohydrate inhibitors could also be readily determined.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg21fg33sd" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>