Stereocontrolled Synthesis of Trichodermatide A1. Issue 13 (18th February 2013)

• Record Type: Journal Article
• Authors: Shigehisa, Hiroki; Suwa, Yoshihiro; Furiya, Naho; Nakaya, Yuki; Fukushima, Minoru; Ichihashi, Yusuke; Hiroya, Kou
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 13(2013)
• Page Start: 3646
• Page End: 3649
• Publication Date: 2013-02-18
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201210099
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Hard core made easy</bold>: The pentacyclic core of trichodermatide A was stereoselectively synthesized from a bis(1, 3‐cyclohexanedione) derivative by a ring‐closing reaction followed by an intramolecular ketal formation (see scheme; PPTS=pyridinium <italic>p</italic>‐toluenesulfonate). The first total synthesis of trichodermatide A was then completed by the introduction of three hydroxy groups.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1v8chxkn" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>