Stereocontrolled Synthesis of Trichodermatide A1. Issue 13 (18th February 2013) - Shigehisa, Hiroki
Abstract Hard core made easy: The pentacyclic core of trichodermatide A was stereoselectively synthesized from a bis(1, 3‐cyclohexanedione) derivative by a ring‐closing reaction followed by an intramolecular ketal formation (see scheme; PPTS=pyridinium p‐toluenesulfonate). The first total synthesis of trichodermatide A was then completed by the introduction of three hydroxy groups.