Copper‐Catalyzed Oxidative Cross‐Coupling of Sulfoximines and Alkynes1. Issue 12 (12th February 2013)

• Record Type: Journal Article
• Authors: Wang, Long; Huang, He; Priebbenow, Daniel L.; Pan, Fang‐Fang; Bolm, Carsten
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 12(2013)
• Page Start: 3478
• Page End: 3480
• Publication Date: 2013-02-12
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201209975
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A 'Cu'te couple</bold>: A synthetically useful protocol for the preparation of N‐alkynylated sulfoximines (yne sulfoximines) has been developed. The method involves a mild copper‐catalyzed oxidative cross‐coupling of NH‐sulfoximines and terminal alkynes (see scheme). The corresponding N‐acyl sulfoximines were also obtained selectively after acid‐catalyzed hydrolysis of the yne sulfoximines.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1v78m23p" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>