Asymmetric Enzymatic Hydration of Hydroxystyrene Derivatives1. Issue 8 (17th January 2013)

• Record Type: Journal Article
• Authors: Wuensch, Christiane; Gross, Johannes; Steinkellner, Georg; Gruber, Karl; Glueck, Silvia M.; Faber, Kurt
• Is Part Of: Angewandte Chemie international edition. Volume 52:Issue 8(2013)
• Page Start: 2293
• Page End: 2297
• Publication Date: 2013-01-17
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201207916
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>More than one activity</bold>: Owing to their hydratase activity, phenolic acid decarboxylases catalyze the regio‐ and stereoselective addition of H₂O across the CC double bond of hydroxystyrene derivatives yielding (<italic>S</italic>)‐4‐(1‐hydroxyethyl)phenols with up to 82 % conversion and 71 % <italic>ee.</italic> Based on structure analysis and molecular docking simulations, a catalytic mechanism for this novel enzymatic reaction is proposed.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg1xm2h2p7" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>