Asymmetric Enzymatic Hydration of Hydroxystyrene Derivatives1. Issue 8 (17th January 2013) - Wuensch, Christiane
Abstract More than one activity: Owing to their hydratase activity, phenolic acid decarboxylases catalyze the regio‐ and stereoselective addition of H2O across the CC double bond of hydroxystyrene derivatives yielding (S)‐4‐(1‐hydroxyethyl)phenols with up to 82 % conversion and 71 % ee. Based on structure analysis and molecular docking simulations, a catalytic mechanism for this novel enzymatic reaction is proposed.