Dietary phosphatidylinositol protects C57BL/6 mice from concanavalin A‐induced liver injury by modulating immune cell functions. Issue 9 (8th May 2013)

• Record Type: Journal Article
• Authors: Inafuku, Masashi; Nagao, Koji; Inafuku, Ayako; Yanagita, Teruyoshi; Taira, Naoyuki; Toda, Takayoshi; Oku, Hirosuke; Gescher, Andreas
• Is Part Of: Molecular nutrition & food research. Volume 57:Issue 9(2013:Sep.)
• Page Start: 1671
• Page End: 1679
• Publication Date: 2013-05-08
• Subjects: Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.201200607
• Languages: English
• ISSNs: 1613-4125

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mnfr1974-sec-0010" sec-type="section"> <title>Scope</title> <p>Several recent studies have demonstrated that phospholipids (PLs) supplementation can modulate the function of cultured‐immune cells. Furthermore, dietary PLs have been shown to ameliorate inflammatory processes and immune responses in arthritic and diabetic murine models, respectively. Thus, the aim of this study was to examine the immune‐modulating activities of dietary soybean PLs in mice, with particular emphasis on the immune cell functions.</p> </sec> <sec id="mnfr1974-sec-0020" sec-type="section"> <title>Methods and results</title> <p>Mice were fed semisynthetic diets for 6 weeks, which contained either 7% soybean oil or 5% soybean oil plus 2% of either PL: phosphatidylcholine (PC), phosphatidylinositol (PI), or phosphatidylserine (PS). Production of concanavalin A (Con A)‐induced proinflammatory cytokines was significantly decreased in the splenocytes isolated from mice fed PI compared to other lipids. Supplementation of the diet with PI, but not with the other lipids, significantly suppressed the proinflammatory cytokine serum levels and the development of Con A‐induced liver damages.</p> </sec> <sec id="mnfr1974-sec-0030" sec-type="section"> <title>Conclusion</title> <p>These observations suggest that dietary PI influenced immune functions, resulting in the prevention of pathogenesis and development of the liver injury in mice.</p> </sec> </abstract>