Curcuminoids exert glucose‐lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double‐blind, placebo‐controlled trial. Issue 9 (29th August 2012)

• Record Type: Journal Article
• Authors: Na, Li‐Xin; Li, Ying; Pan, Hong‐Zhi; Zhou, Xian‐Li; Sun, Dian‐Jun; Meng, Man; Li, Xiao‐Xia; Sun, Chang‐Hao; Gescher, Andreas
• Is Part Of: Molecular nutrition & food research. Volume 57:Issue 9(2013:Sep.)
• Page Start: 1569
• Page End: 1577
• Publication Date: 2012-08-29
• Subjects: Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.201200131
• Languages: English
• ISSNs: 1613-4125

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mnfr1810-sec-0010" sec-type="section"> <title>Scope</title> <p>We previously found that curcuminoids decreased blood glucose and improved insulin resistance by reducing serum free fatty acids (FFAs) and increasing fatty acid oxidation in skeletal muscle of diabetic rats. This study was to investigate whether curcuminoids have beneficial effects on type 2 diabetic patients, and its possible mechanisms.</p> </sec> <sec id="mnfr1810-sec-0020" sec-type="section"> <title>Methods and results</title> <p>Overweight/obese type 2 diabetic patients (BMI ≥ 24.0; fasting blood glucose ≥ 7.0 mmol/L or postprandial blood glucose ≥11.1 mmol/L) were randomly assigned to curcuminoids (300 mg/day) or placebo for 3 months. Bodyweight, glycosylated hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>, <sub>%</sub>), serum fasting glucose, FFAs, lipids, and lipoprotein lipase (LPL) were determined. A total of 100 patients (curcuminoids, <italic>n</italic> = 50; placebo, <italic>n</italic> = 50) completed the trial. Curcuminoids supplementation significantly decreased fasting blood glucose (<italic>p</italic> < 0.01), HbA<sub>1c</sub> (<italic>p</italic> = 0.031), and insulin resistance index (HOMA‐IR) (<italic>p</italic> < 0.01) in type 2 diabetic patients. Curcuminoids also led to a significant decrease in serum total FFAs (<italic>p</italic> < 0.01), triglycerides (<italic>P</italic> = 0.018), an increase in LPL activity (<italic>p</italic> < 0.01).</p> </sec> <sec id="mnfr1810-sec-0030" sec-type="section"> <title>Conclusion</title> <p>These findings suggest a glucose‐lowering effect of curcuminoids in type 2 diabetes, which is partially due to decrease in serum FFAs, which may result from promoting fatty acid oxidation and utilization.</p> </sec> </abstract>