Correlation of muscle BOLD MRI with transcutaneous oxygen pressure for assessing microcirculation in patients with systemic sclerosis. Issue 4 (25th February 2013)

• Record Type: Journal Article
• Authors: Partovi, Sasan; Aschwanden, Markus; Jacobi, Bjoern; Schulte, Anja‐Carina; Walker, Ulrich A.; Staub, Daniel; Imfeld, Stephan; Broz, Pavel; Benz, Daniela; Zipp, Lisa; Jaeger, Kurt A.; Takes, Martin; Robbin, Mark R.; Huegli, Rolf W.; Bilecen, Deniz
• Is Part Of: Journal of magnetic resonance imaging. Volume 38:Issue 4(2013)
• Page Start: 845
• Page End: 851
• Publication Date: 2013-02-25
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24046
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24046-sec-0001" sec-type="section"> <title>Purpose</title> <p>To prospectively compare calf muscle BOLD MRI with transcutaneous oxygen pressure (TcPO<sub>2</sub>) measurement in patients with systemic sclerosis (SSc) and healthy volunteers and thereby get insight into the pathogenesis of vasculopathy in this connective tissue disorder.</p> </sec> <sec id="jmri24046-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Twelve patients with SSc (6 women and 6 men, mean age 53.5 ± 10.0 years) and 12 healthy volunteers (4 men and 8 women, mean age 47 ± 12.1 years) were examined using muscle BOLD MRI and TcPO<sub>2</sub>. A cuff compression at mid‐thigh level was performed to provoke ischemia and reactive hyperemia. BOLD measurements were acquired on a 3 Tesla whole body‐scanner in the upper calf region using a multi‐echo EPI‐sequence with four echo‐times (TE: 9/20/31/42 ms) and a repetition time of 2 s. Empirical cross‐correlation analysis depending on time lags between BOLD‐ and TcPO<sub>2</sub>‐measurements was performed.</p> </sec> <sec id="jmri24046-sec-0003" sec-type="section"> <title>Results</title> <p>Maximal cross‐correlation of BOLD T2*‐ and TcPO<sub>2</sub>‐measurements was calculated as 0.93 (healthy volunteers) and 0.90 (SSc patients) for a time lag of approximately 40 s. Both modalities showed substantial differences regarding time course parameters between the SSc patients and healthy volunteers.</p> </sec> <sec id="jmri24046-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Skeletal muscle BOLD MRI correlated very well with TcPO<sub>2</sub>. T2* changes seem to reflect reoxygenation deficits in deeper muscle tissue of SSc patients. J. Magn. Reson. Imaging 2013;38:845–851. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>