Correlation of muscle BOLD MRI with transcutaneous oxygen pressure for assessing microcirculation in patients with systemic sclerosis. Issue 4 (25th February 2013) - Partovi, Sasan
Abstract Purpose To prospectively compare calf muscle BOLD MRI with transcutaneous oxygen pressure (TcPO2) measurement in patients with systemic sclerosis (SSc) and healthy volunteers and thereby get insight into the pathogenesis of vasculopathy in this connective tissue disorder. Materials and Methods Twelve patients with SSc (6 women and 6 men, mean age 53.5 ± 10.0 years) and 12 healthy volunteers (4 men and 8 women, mean age 47 ± 12.1 years) were examined using muscle BOLD MRI and TcPO2. A cuff compression at mid‐thigh level was performed to provoke ischemia and reactive hyperemia. BOLD measurements were acquired on a 3 Tesla whole body‐scanner in the upper calf region using a multi‐echo EPI‐sequence with four echo‐times (TE: 9/20/31/42 ms) and a repetition time of 2 s. Empirical cross‐correlation analysis depending on time lags between BOLD‐ and TcPO2‐measurements was performed. Results Maximal cross‐correlation of BOLD T2*‐ and TcPO2‐measurements was calculated as 0.93 (healthy volunteers) and 0.90 (SSc patients) for a time lag of approximately 40 s. Both modalities showed substantial differences regarding time course parameters between the SSc patients and healthy volunteers. Conclusion Skeletal muscle BOLD MRI correlated very well with TcPO2. T2* changes seem to reflect reoxygenation deficits in deeper muscle tissue of SSc patients. J. Magn. Reson. Imaging 2013;38:845–851. © 2013 Wiley Periodicals, Inc.